Notice: This is NOT an official government website. We are not affiliated with any government agency.
Back to Articles
Side Effects

Managing Fatigue on GLP-1 Medications

GOV Health Report TeamDecember 9, 20258 min read

Notice: This is NOT a government website. GOV Health Report is an independent review site. Always consult a healthcare provider before starting any treatment.

Person managing energy levels during weight loss
Article Content

Fatigue is reported by some people starting GLP-1 medications, especially during the initial weeks. Understanding the causes and solutions can help you maintain your energy levels during treatment.

Common Causes of Fatigue

  • • Reduced calorie intake (your body is adjusting)
  • • Dehydration from GI side effects
  • • Blood sugar changes
  • • Nutrient deficiencies from eating less
  • • Poor sleep from lifestyle changes

Strategies to Boost Energy

Prioritize Protein

Protein provides sustained energy. Aim for 60-100g daily, even with reduced appetite. Start meals with protein to ensure you get enough.

Stay Hydrated

Dehydration is a major cause of fatigue. Aim for 8+ glasses of water daily. Add electrolytes if you've had GI issues.

Don't Skip Meals

Even if not hungry, eat small, regular meals to maintain blood sugar and energy. Extreme calorie restriction leads to fatigue.

Consider a Multivitamin

Eating less can lead to vitamin deficiencies. A daily multivitamin, especially with B vitamins and iron, can help maintain energy.

Light Exercise

It seems counterintuitive, but light activity like walking can actually boost energy levels. Start slow and listen to your body.

When Fatigue May Indicate a Problem

See your doctor if fatigue is:

  • • Severe or debilitating
  • • Getting worse over time
  • • Accompanied by other symptoms (dizziness, rapid heartbeat)
  • • Not improving after several weeks

Official Summary

Fatigue on GLP-1 medications is usually temporary and related to reduced calorie intake and adjustment period. Prioritize protein, hydration, and regular meals. Most people find their energy improves as their body adapts.

Get Started with GLP-1 Treatment

These top-rated providers offer semaglutide and tirzepatide with ongoing medical support.

#1 Recommended
#1
Most Popular

CoreAge Rx

5

Premium GLP-1 Weight Loss Program

  • FDA-approved GLP-1 medications
  • Personalized treatment plans
  • Board-certified physicians
Free Shipping
Fast Start
Starting at $99/mo
Get Started
FDA-approved treatments
#2
Best Value

Henry Meds

4.7

Affordable GLP-1s Starting at $199/month

  • Compounded GLP-1s Starting at $199/month
  • No Hidden Fees, Free Shipping Included
  • Licensed Physicians in All 50 States
Free Shipping
Fast Start
Get Started
FDA-approved treatments
#3
Most Trusted

Hims

4.6

Trusted by Millions for Weight Loss

  • GLP-1 Medications From $199/month
  • Discreet Packaging & Fast Delivery
  • 24/7 Access to Healthcare Providers
Free Shipping
Fast Start
Get Started
FDA-approved treatments

Medical Disclaimer

This article is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before starting any weight loss treatment. GOV Health Report is NOT a medical website and we are not licensed healthcare professionals. Individual results and risks may vary.

Content Notice: Information on this page is compiled from publicly available sources and may be AI-assisted. Always verify information with official sources and consult healthcare professionals for medical decisions.