Headaches are reported by 10-15% of people starting GLP-1 medications. While usually mild and temporary, understanding why they happen and how to manage them can help you stay comfortable during treatment.
Why GLP-1s May Cause Headaches
- • Dehydration from reduced fluid intake or GI side effects
- • Blood sugar changes during adjustment period
- • Reduced calorie intake (similar to dieting headaches)
- • Caffeine reduction if changing eating habits
- • Temporary adjustment as body adapts
Tips for Relief
Stay Well Hydrated
Dehydration is the most common cause. Aim for 8+ glasses of water daily. Set reminders if you're not feeling thirsty due to appetite suppression.
Eat Regularly
Even with reduced appetite, try to eat small meals throughout the day. Skipping meals can trigger headaches from low blood sugar.
Monitor Caffeine Intake
If you've reduced coffee or soda due to appetite changes, caffeine withdrawal can cause headaches. Taper gradually rather than stopping suddenly.
Over-the-Counter Pain Relief
Acetaminophen or ibuprofen can help occasional headaches. Avoid overuse, which can cause rebound headaches.
When to Seek Medical Attention
Contact your doctor if you experience:
- • Severe or sudden headaches
- • Headaches with vision changes
- • Headaches with confusion or slurred speech
- • Persistent headaches that don't improve
- • Headaches with fever or stiff neck
Official Summary
Headaches on GLP-1 medications are usually mild and related to dehydration or dietary changes. Stay hydrated, eat regularly, and taper caffeine gradually. Most headaches resolve within the first few weeks of treatment.