UpScript Reviews
The telehealth and pharmacy behind Contrave at $99/month
IMPORTANT: GOV Health Report is NOT a government website. This is an independent review. Consult healthcare professionals before medical decisions.
Contrave $99/month; $45 visit fee only if using an outside pharmacy
Section 1: Executive Summary
UpScript is infrastructure more than a brand: it is the telehealth-plus-pharmacy platform that manufacturers use to run their own direct-to-patient programs, and it says it has served over a million patients. The clearest example is Contrave (naltrexone/bupropion), where UpScript delivers the CurAccess program at $99 per month with free shipping. The consultation model adapts to state law — video, audio, or digital review depending on where you live — and UpScript notes that in many cases it does not charge a consultation or processing fee when it fulfills the prescription itself, with a $45 physician visit fee applying if you route the prescription to an outside pharmacy instead. For people who cannot take a GLP-1 or want a non-GLP-1 option, this is one of the cheapest legitimate paths to a branded FDA-approved weight medication.
Documented Strengths
5 Items- 1Contrave at $99/month through the CurAccess program with free shipping
- 2Over a million patients served through manufacturer partnerships
- 3No consultation or processing fee in many cases when UpScript fills the prescription
- 4Full refund of medication and consultation fee if you are not prescribed
- 5FSA and HSA cards accepted, same-day shipping for early consults
Noted Limitations
4 Items- 1Not available in North Carolina or Washington DC for most products
- 2Contrave is not available in Florida through this pathway
- 3Does not accept health insurance for the online visit
- 4Contrave is a different drug class from GLP-1s with a different efficacy profile
Section 2: Medications Offered
Note: Medication availability may vary. Compounded medications are not FDA-approved. Always verify current offerings directly with the provider.
Section 3: How It Works
Complete a medical questionnaire that a healthcare provider will review
Check out, providing shipping and payment information for the virtual consultation
Conduct your consultation — video, audio, or digital review depending on your state's rules
If approved, the prescription goes to UpScript's pharmacy for review
Medication is packaged and shipped directly to you, same day for consults completed by 1 PM PST
Section 4: Eligibility Requirements
- BMI of 30 or greater, or 27 or greater with at least one weight-related condition such as high blood pressure, type 2 diabetes, or high cholesterol
- Must be 18 years or older
- Not for people with uncontrolled hypertension, seizure disorders, or eating disorders — see full prescribing information
- Not for those using opioids or undergoing opioid withdrawal
- Resident of a state UpScript serves — not North Carolina or Washington DC for most products, and Contrave is not available in Florida
Important: Final eligibility is determined by a licensed healthcare provider after reviewing your complete medical history.
Section 5: Potential Side Effects
WARNING: This is not a complete list. Serious side effects may occur. Seek immediate medical attention if you experience severe symptoms. Consult your healthcare provider for complete safety information.
Section 6: Service Features
Insurance & Payment
UpScript does not accept health insurance for the online visit. It accepts credit, debit, and prepaid cards plus FSA and HSA cards. Contrave through the CurAccess program is $99 per month regardless of insurance, though the manufacturer notes it may cost less if your insurance covers it through a pharmacy instead.
Shipping Information
Free shipping is available on Contrave through CurAccess. For consultations completed by 1 PM PST, prescriptions ship the same day; after that, the next business day. Weekend consultations ship Monday.
Customer Support
Patient support by email at service@UpScript.com, phone, and live chat, with the option to email the pharmacy or healthcare provider directly.
Cancellation Policy
Monthly subscriptions can be cancelled at any time, and auto-refill enrollment can be cancelled from your account or by contacting patient support.
Section 7: Additional Services
Section 8: Program Structure
Brand-name FDA-approved medication. Contrave contains naltrexone and bupropion, two drugs individually on the market for over 30 years, combined and approved for chronic weight management. No compounding is involved.
A U.S.-licensed prescriber reviews your medical history and determines whether the prescription is appropriate. The consultation format — video, audio, or digital — is determined by your state's telehealth regulations, and Florida patients on Contrave must be re-evaluated after two to four weeks per state rules.
UpScript does not publish a mandatory pre-treatment lab requirement for Contrave.
UpScript's own pharmacy fills the prescription and ships it to you. You may instead route the prescription to a local pharmacy, in which case a $45 healthcare provider visit fee applies.
Monthly, with optional auto-refill you can cancel at any time.
Section 9: Cost Breakdown
None. In many cases UpScript does not charge a consultation or processing fee when it fulfills the prescription, because that cost is built into the medication price. A $45 physician consultation fee applies if you send the prescription to an outside pharmacy.
Contrave is $99 per month through the CurAccess program with free shipping. Other products on the platform are priced individually.
Clear and published for Contrave: if you are not prescribed the medication during your telehealth visit, you are refunded the full cost of the medication and the physician consultation fee. Per FDA regulations, prescription medication cannot be returned once it has shipped from the pharmacy.
Yes. UpScript explicitly accepts FSA and HSA cards as forms of payment.
Section 10: Documented Limitations
- Unavailable in North Carolina and Washington DC for most products
- Contrave specifically is not available in Florida through this pathway
- Contrave produces less weight loss on average than GLP-1 medications
- Carries a boxed warning regarding suicidal thoughts and behaviors
- No health insurance accepted for the visit
Section 11: Alternatives to Consider
Section 12: Frequently Asked Questions
What is UpScript?
A telehealth and pharmacy platform that manufacturers use to run direct-to-patient programs. It says it has served over a million patients, and the most visible example is Contrave's CurAccess program.
How much does Contrave cost through UpScript?
$99 per month with free shipping through the CurAccess program. If your insurance covers Contrave at a pharmacy, it may cost less that way.
Is there a consultation fee?
In many cases no — UpScript states it does not charge a consultation or processing fee when it fulfills the prescription, since that cost is included in the medication price. A $45 fee applies if you send the prescription to an outside pharmacy instead.
What happens if I am not approved?
UpScript states that if you are not prescribed the medication during your telehealth visit, you will be refunded the full cost of the medication and the physician consultation fee.
How does Contrave compare to a GLP-1?
Less weight loss on average. Across three 56-week studies, 46% of patients on Contrave lost 5% or more of body weight versus 23% on placebo. GLP-1 trials typically show 15% to 21% average loss. Contrave is cheaper, oral, and a reasonable option if a GLP-1 is unsuitable or unaffordable.
Assessment Recommendation
Best suited for: People who cannot take or do not want a GLP-1 and want an inexpensive, FDA-approved oral alternative
Medical Disclaimer
This assessment is for general informational purposes only and is not medical advice, a diagnosis, or a treatment recommendation. GOV Health Report is an independent publisher, is not affiliated with any government agency, and does not practice medicine or dispense medication. GLP-1 medications are prescription drugs with serious potential risks and are not appropriate for everyone. Only a licensed clinician who has evaluated you can determine whether treatment is safe for you. Compounded medications are not FDA-approved and are not reviewed by the FDA for safety, effectiveness, or quality. Always talk to a qualified healthcare professional before starting, stopping, or changing any medication, and read our full medical disclaimer.
Date reviewed: August 5, 2026. Details on this page reflect information published by the provider as of that date and can change without notice.
UpScript
Contrave $99/month; $45 visit fee only if using an outside pharmacy
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